脑梗死合并糖尿病阿司匹林抵抗的研究进展

Research Progress in Aspirin Resistance in the Patients with Cerebral Infarction Companied with Diabetes

阿司匹林以其抗血小板聚集作用，目前广泛用于缺血性心脑血管病的一、二级防治。但在临床中发现，并非所有患者均能在阿司匹林治疗下获益，有部分患者在长期规律服用阿司匹林过程中仍发生心脑血管血栓栓塞事件，这种现象称为阿司匹林抵抗。糖尿病被公认为脑梗死发病的独立危险因素。有研究显示糖尿病也是阿司匹林抵抗的独立危险因素，导致脑梗死的发病率及复发率高于非糖尿病患者。文章对脑梗死合并糖尿病患者阿司匹林抵抗的可能机制及其临床干预等进行综述。

Aspirin has significant anti - platelet aggregation and is widely used in primary and secondary prevention of ischemic heart and cerebrovascular disease. But it is found that in clinical not all of the patients can get benefit from aspirin therapy and cardio- vascular thromboembolic events are still be occured in some patients with long - term regular aspirin therapy, which is known as aspirin resistance. Diabetes is recognized as an independent risk factor for cerebral infarction. Studies have shown that diabetes is also an in- dependent risk factor for aspirin resistance, which lead to the incidence of cerebral infarction, and the recurrence rate is higher than that in patients without diabetes. This article reviews the mechanisms that Aspirin resistance in the patients with cerebral infarction companied with diabetes.