摘要
目的综述国内外研究人员从链霉菌中发现的抗血栓活性物质。方法检索了近几年国内外发表的相关文献,进行分析总结。结果人血液中的纤溶酶和纤溶酶原激活剂都属于丝氨酸蛋白酶,而链霉菌产生的具有纤溶活性的蛋白酶大多也属丝氨酸蛋白酶家族,且活性很好。结论链霉菌产生的纤溶活性蛋白酶具有诱人的应用前景,链霉菌可以作为抗血栓药物的新型来源。
Objective To summarize the research progress of antithrombotic agents from Streptomyces .Methods The related do-mestic and foreign literatures in recent years were analyzed and summarized .Results Streptomyces can produce high potency fi-brinolytic enzymes ,which belong to the serine protease as plasmin and plasminogen activator in human blood .Conclusion The antithrombotic agents screened from Streptomyces have attractive prospective ,and Streptomyces can be a new resource of the an-tithrombotic drugs .
出处
《西北药学杂志》
CAS
2014年第6期658-660,共3页
Northwest Pharmaceutical Journal
关键词
链霉菌
抗血栓药物
纤溶酶
Streptomyces antithrombotic agents fibrinolytic enzyme