肺部铜绿假单胞菌感染前后肺组织角质细胞生长因子的变化研究

The change of keratinocyte growth factor in lung tissue before and after pulmonary Pseudomonas aeruginosa infection

目的观察与分析肺部铜绿假单胞菌(PAE)感染前后患者肺组织角质细胞生长因子(KGF)的变化情况,并研究其临床意义。方法将2010年12月到2013年12月于沈阳军区总医院接受治疗的60例肺炎患者作为研究对象,分别于其感染前后收集肺组织标本,检测感染前后患者肺组织角质细胞生长因子的表达水平。结果在感染PAE后,患者肺组织角质细胞生长因子蛋白表达水平呈明显上升的态势,并于感染3 d后到达峰值。相较感染铜绿假单胞菌前,患者肺组织角质细胞生长因子蛋白表达水平明显提升,感染前后对比差异有统计学意义(P<0.05)。结论在急性肺损伤的诊断与治疗中,重视对患者肺组织KGF蛋白表达水平的研究,及时实施KGF辅助干预,对抑制感染,控制肺炎的进展有十分重要的作用。

Objective To observe and analyze the change of keratinocyte growth factor（ KGF） in lung tissue of patients with pulmonary Pseudomonas aeruginosa（ PAE） infection,and explore its clinical significance. Methods60 cases of patients with pneumonia during December 2010 and December 2013 in our hospital were selected as the subjects; their lung tissue samples were collected. The expressions of KGF in lung tissue before and after infection were detected. Results After PAE infection,the expression of KGF in the lung tissue of patients increased obviously,and reached peak value 3 days after infection. Compared with the expression level before the infection of Pseudomonas aeruginosa,the difference was significant（ P〈0. 05）. Conclusion In the diagnosis and treatment of acute lung injury,it is important to learn the expression level of KGF protein in lung tissue of patients and take appropriate interventions to inhibit the infection and the progression of pneumonia.