病理状态下颅内静脉窦压与颅内压的相关性研究

Analysis of correlation between intracranial venous sinus pressure and intracranial pressure in pathological conditions

目的探讨病理状态下颅内静脉窦压与颅内压的关系。方法选择100例中重型颅脑损伤住院患者,收集其颅内静脉窦压及颅内压的相关数据,并进行相关性分析。结果在颅脑损伤早期,颅内压低于4.0 k Pa时,颅内压与颅内静脉窦压呈正相关(r=0.577,P<0.001)。随着颅内压的逐步升高,颅内静脉窦压增加并不明显,出现一相对的平台期,当颅内压上升至6.25 k Pa时,颅内静脉窦压反较平台期略有下降。结论在颅脑损伤早期,颅内压与颅内静脉窦压存在一压力梯度,保持颅内静脉的通畅对控制颅内压的升高十分重要。

Objective To explore the correlation between intracranial venous sinus pressure （VSP） and intracranial pressure （ICP） in pathological conditions. Methods Clinical data from 100 cases of hospital- ized patients with moderate to severe craniocerebral injury were collected and the obtained VSP and ICP were subject to correlation analysis. Results In the early stage of brain injury, ICP was positively correlated with VSP when ICP was 〈 4. 0 kPa （ r = 0. 577, P 〈 0. 001 ）. VSP did not increase significantly along with the ele- vation of ICP and reached a relative plateau stage. When ICP increased up to 6. 25 kPa, VSP began to decline instead, lower than the level during the plateau stage. Conclusions A pressure gradient could be found be- tween ICP and VSP during the early stage injury. Smooth flow of intracranial vein plays a pivotal role in control- ling the increase of ICP.