摘要
1例17岁女性患者因感染性心内膜炎静脉滴注头孢美唑钠（2 g，3次/d）和阿米卡星（0.4 g，1次/d）。用药6天血常规检查示白细胞计数23.4×10^9/L，中性粒细胞0.92，中性粒细胞绝对值21.6×10^9/L。用药第13天血常规检查示白细胞计数6.6×10^9/L，中性粒细胞0.70，中性粒细胞绝对值4.6×10^9/L。第14天停用阿米卡星，继续原剂量静脉滴注头孢美唑钠。用药第28天血常规检查示白细胞计数2.6×10^9/L，中性粒细胞0.37，中性粒细胞绝对值1.0×10^9/L。停用头孢美唑钠，更换为万古霉素粉针0.5 g，1次/8 h静脉滴注。更换药物后第7天，血白细胞计数6.1×10^9/L，中性粒细胞0.60，中性粒细胞绝对值3.7×10^9/L。
A 17-year-old woman with infectious endocarditis received an IV infusion of cefmetazole sodium 2 g three times daily and amikacin 0. 4 g once daily. On day 6 of treatment,blood routine examination revealed the following levels：leucocyte count 23. 4 × 10^9/L, neutrophile granulocyte 0. 92,neutrophil granulocyte absolute value 21. 6 × 10^9/L. On day 13 of treatment,blood routine examination revealed the following levels：leucocyte count 6. 6 × 10^9/L,neutrophile granulocyte 0. 70,neutrophil granulocyte absolute value 4. 6 × 10^9/L. On day 14,amikacin was withdrawn and IV infusion of cefmetazole sodium was given at the original dose sequentially. On day 28 of treatment,blood routine examination revealed the following values：leucocyte count 2. 6 × 10^9/L,neutrophile granulocyte 0. 37,neutrophil granulocyte absolute value 1. 0 × 10^9/L. Cefmetazole sodium was withdrawn and changed to an IV infusion of vancomycin 0. 5 g every 8 hours. Seven days after replacement of drug,blood routine examination revealed the following：leucocyte count 6. 1 × 10^9/L,neutrophile granulocyte 0. 60,neutrophil granulocyte absolute value 3. 7 × 10^9×/L.
出处
《药物不良反应杂志》
CSCD
2014年第5期300-301,共2页
Adverse Drug Reactions Journal
