男性抑郁症患者药物治疗前后性功能变化的临床研究

Changesin the sexual function of male patients with depression before and after treatment

目的:探讨男性抑郁症患者药物治疗前后性功能变化情况,以更好的掌握和治疗该类疾病,提高抑郁症患者治疗后性功能。方法:选取2010年4月至2013年4月90例抑郁症患者为研究对象,比较治疗前后在性功能指标孕酮(PROG)、雌二醇(E2)、睾酮(T)、黄体生成素(LH)、促卵泡激素(FSH)、催乳素(PRL)的变化情况。结果:治疗前后在HAMD-17、BSDSRS、IIEF、CISFPE和PROG、E2、T、LH、FSH、PRL比较差异有统计学意义(P<0.05)。结论:男性抑郁症合并性功能障碍发生率高,多数药物在缓解抑郁同时不能改善性功能状况,且有加重趋势,临床上要选择对性功能影响较低的抗抑郁症药物。

Objectives： To investigate changes in the sexual function of male patients with depression before and after drug treatment in order to better understand and treat the disease, and improve the sexual function of such patients after treatment. Methods： 90 patients with depression from April 2010 to April 2013 were selected for the study, and the sexual function indexes including levels of progesterone （PROG） , estradiol （ E2 ）, testosterone （T）, luteinizing hormone （changes in LH）, follicle - stimulating hormone （FSH） and prolactin （PRL） before and after treatment were compared. Results： Changes in the HAMD - 17, BSDSRS, fIEF, CISFPE and PROG, E2, T, LH, FSH and PRL before and after treatment was of statistically significant differences （ P 〈 0. 05 ）. Conclusion： Male patients with depression are of high incidence of sexual dysfunction, while most drugs in relieving depression cannot improve sexual function; therefore, antidepressant drugs with a smaller impact on sexual function should be chosen in clinical practice.