雷公藤多苷诱导生精障碍大鼠模型的研究进展

Research progress in the model of spermatogenic impairment rats induced by Tripterygium Glycosides

雷公藤多苷所具有的生精抑制作用为研究人类生精障碍型不育的病因、发病机制和病理生理改变提供了重要线索。男性不育的病因复杂,发病机制至今尚未完全清楚,如果能够建立适当的生精障碍动物模型,就可以极大的促进药物作用机制的研究和临床药物的开发。本文主要从目前实验研究雷公藤多苷诱导生精障碍大鼠模型的大鼠选择及饲养、溶剂的选择及给药方式、造模时间及剂量等方面做一综述,探讨如何合理利用雷公藤多苷时间与剂量的关系诱导生精障碍模型,为解决男性不育问题提供帮助。

Tripterygium glycoside has the function of spermatogenic inhibition, which provides important clues for the study of human spermatogenesis dysfunction infertility etiology, pathogenesis and pathophysiology. Since causes of male infertility are complicated, the pathogenesis is still not completely clear; therefore, if we can establish appropriate animal dyszoospermia model, it can promote the development of study on the mechanism of ac- tion of the drug and clinical medicine greatly. This paper mainly summarized the rat selection and breeding, solvent selection and administration, molding time and dose of experimental studies of model spermatogenic impairment which are induced by Tripterygium Glycosides, to explore how to take advantage of the rational use of tripterygium glycosides in time and dose to induce spermatogenesis disturbance model, so as to help solve male infertility prob- lems.