孕期抗梅毒治疗对妊娠结局及新生儿预后的影响

Effect of anti syphilis therapy on the prognosis of pregnancy and neonatal outcomes

目的:探讨抗梅毒治疗对妊娠患者妊娠结局以及新生儿预后的影响。方法:回顾性分析2012年12月至2013年11月科室妊娠梅毒患者116例临床资料,其中梅毒规范治疗患者86例列为治疗组,未治疗或者治疗不规范患者30例列为对照组,对比两组患者妊娠结局、新生儿预后等情况。结果:治疗组发生3例(3.49%)不良妊娠结局,明显低于对照组8例(26.67%),对比差异有统计学意义(χ2=16.668,P=0.002);治疗组发生5例(5.95%)不良新生儿结局,低于对照组6例(26.09%),对比差异有统计学意义(χ2=14.628,P=0.003);治疗组新生儿RPR全部转阴,明显优于对照组8例(44.44%)转阴,对比差异有统计学意义(χ2=11.158,P=0.013)。结论:对合并梅毒妊娠患者实施规范的抗梅毒治疗是关键的改善妊娠结局以及新生儿预后的因素。

Objectives： To investigate the effect of anti syphilis treatment in pregnancy on the pregnancy outcome and neonatal prognosis. Methods： A retrospective analysis was conducted on the clinical data of 116 preg- nant women with syphilis in our department from December 2012 - November 2013. The 86 patients having re- ceived standard treatment were selected as treatment group, while the rest were as control group. The pregnancy out-come and neonatal prognosis of the two groups were compared. Results： There were 3 cases （3.49%） of adverse pregnancy outcomes in the treatment group, significantly lower than the control group of 8 cases （26.67%）, with statistically significant differences （X2 = 16. 668, P = 0. 002） ; there were 5 cases （5.95%） of adverse neonatal outcome in the treatment group, lower than that of the control group of 6 cases （26.09%）, with statistically signifi- cant differences （X2 = 14. 628, P = 0.003 ） ; all RPR of the treatment group turned to negative, significantly better than the control group where only 8 eases （ 44.44% ） turned to negative, with statistically significant differences （X2 = 11. 158, P = 0.013）. Conclusion： Standard anti syphilis treatment is a key factor in improving the pregnancy outcome and neonatal prognosis of pregnant patient with syphilis.