育龄妇女生殖道支原体、衣原体感染检测及支原体感染药敏分析

The chlamydia and mycoplasma infection detection and mycoplasma susceptibility testing analysis of women of childbearing age

目的:探讨淳安县育龄妇女生殖道支原体、衣原体感染情况,并对支原体感染患者对抗生素的敏感性进行分析。方法:选取淳安县妇科门诊就诊的育龄期女性1513例,采集宫颈处单层柱状上皮细胞进行检测和药敏试验。结果:1513例患者中1448例患者检出支原体和/或衣原体,检出率为95.70%,其中以单纯感染解脲支原体(Uu)者最多,有947例,占62.59%;其次是同时感染Uu与人型支原体(Mh)者,检出313例,占20.69%。单纯Uu感染者对罗红霉素、克拉霉素、交沙霉素的敏感性较高,而对环丙沙星、可乐霉素以及加替沙星的耐药性较高;单纯Mh感染者对交沙霉素敏感性高,而对罗红霉素、阿奇霉素、克拉霉素以及红霉素的耐药性都超过90%;Uu与Mh联合感染者仅对交沙霉素的敏感性较高,但是也仅有47.65%。即三种类型的支原体感染其对抗生素的敏感性差别较大(P<0.05)。结论:淳安县育龄妇女生殖道支原体、衣原体感染中以单纯Uu感染和Uu与Mh联合感染居多,临床中宜根据药敏试验合理选择抗生素,但是在无药敏试验的情况下交沙霉素可以作为首选药物。

Objectives： To explore the chlamydia and mycoplasma infection status of women of childbearing age in Chun＇ an County as well as analyze the mycoplasma susceptibility testing. Methods： 1513 women of child- bearing age in gynaeeological outpatients of Chun＇ an County were selected, and their cervical epithelium cells were collected for detection and drug susceptibility testing. Results： 1448 cases were detected to have myeoplasma and/ or chlamydia, a detection rate of 95.70%, the most of which was ureaplasma urealytieum （Uu） infection alone, 947 cases accounting for 62.59% ; followed by co - infection of Uu and mycoplasma hominis （ Mh）, 313 cases ac- counting for 20.69%. Patients with simple Uu infection had higher sensitivity for roxithromycin, clarithromycin and josamyein, while high resistance to ciprofloxacin, clarithromyein, and gatifloxacin; Patients with pure Mh infection had high sensitivity to josamycin, while over 90% resistance to roxithromycin, azithromycin, clafithromyein and e- rythromycin; patients with joint infection of Uu and Mh were only highly sensitive to josamycin, which was only 47.65%. There sensitivity to antibiotics of the three types of mycoplasma infection were significantly different （ P 〈 0. 05）. Condusion： For the mycoplasma and ehlamydia infection in women of childbearing age in Chun＇ an Coun- ty, mostly was pure Uu infection and co - infection of Uu and Mh. Reasonable antibiotic should be chosen based on susceptibility testing of antibiotics, but in the case of non - susceptibility testing josamycin may serve as the first choice.