硫酸头孢喹肟在鸡体内的药物动力学研究

Study on pharmacokinetics of cefquinome sulfate in chickens

采用HPLC法测定血浆药物浓度,3P97药物动力学软件处理血药浓度数据,研究硫酸头孢喹肟口服和静注给药在鸡体内的动力学特征。结果表明:静脉注射主要药物动力学参数,表观分布容积(Vd)为1.16L·kg-1,分布半衰期(T1/2α)为0.29h,消除半衰期(T1/2β)为1.69h,曲线下面积(AUC)为6.57mg·(L·h)-1,消除速率CL(s)为1.53L·(kg·h)-1;口服主要药物动力学参数,T1/2α为0.52h,T1/2β为0.88h,达峰时间(tmax)为1.07h,峰浓度(Cmax)为3.63mg·L-1,AUC为9.84mg·(L·h)-1,生物利用度(F)为75.1%。证明硫酸头孢喹肟静注给药体内分布广泛,消除迅速;口服给药吸收迅速,分布广泛,但在鸡体内生物利用度稍低,但可有效控制常见细菌感染。

This experiment was carried out to study the pharmacokinetics of cefquinome sulfate in chickens by oral administration and single intravenous（iv. ）. The concentration-time data in plasma was determined by HPLC and was ana- lyzed with pharmacokinetic-compartment analysis soft （3P97）. The results showed that the concentration-time data of cefquinome sulfate after i.v. admistration at the dose of 10 mg ·kg^-1 in chickens were fitted to a two-compartment open model. The main pharmacokinetic parameters were as follows： Vd 1.16 L ·kg^-1, T1/2α.29 h, T1/2β 1.69h,AUC 6.57 mg · （L· h）^-1 and CL（s） 1.53 L · （kg ·h）^-1. The concentration-time data of cefquinome sulfate after oral admistration at the dose of 20 mg · kg^-1 in chickens were fitted to a one-compartment open model with first order absorbtion. The main pharmacokinetic parameters were as follows： T1/2α, 0. 52 h, T1/2β 0. 88 h, tmax 1.07 h, Cmax 3.63 mg·L^-1 , AUC 9.84 mg· （L · h）^-1 and F 75.1%. The results indicated that the pharmacokinetic characteristics of cefquinome sulfate after i.v. admistration in healthy chickens manifested wide distribution and rapid elimination, and the pharmacokinetic characteristics after oral administration showed rapid absorption, wide distribution but a little lower bioavailability. How- ever it could inhibit infections of common bacteria.