摘要
人参皂苷是人参的主要活性成分,其在心血管方面的作用正在被广泛研究。本文简要介绍了人参皂苷对心血管疾病的药理作用及其药代动力学特点。人参皂苷能够控制心律失常,抑制心肌肥厚和心肌细胞凋亡,抑制炎症,保护血管内皮细胞,改善心肌缺血和心肌缺血/再灌注损伤,从而发挥其保护心血管系统的作用。肠道菌群广泛参与人参皂苷的代谢是其代谢特征之一。
Ginsenosides are the main active ingredients of ginseng, and its role in cardiovascular system is being widely studied. Ginsenosides are able to control arrhythmias, inhibit cardiac hypertrophy and cardiomyocyte apoptosis, inhibit inflammation, protect vascular endothelial, and improve myocardial ischemia and myocardial ischemia/reperfusion injury. The combined effects of multiple mechanisms play an important role in its protection for the cardiovascular system. Variety of intestinal flora which is involved in the metabolism is also one of its metabolic characteristics of ginsenosides.
出处
《药品评价》
CAS
2014年第18期11-15,共5页
Drug Evaluation
关键词
人参皂苷
心血管疾病
药理作用
药代动力学
Ginsenosides
Cardiovascular Disease
Pharmacological Effects
Pharmacokinetics
