血清AFP、CEA、CA125、CA199联合检测对消化系统恶性肿瘤的诊断价值

Diagnostic value of serum AFP, CEA, CA125 and CA199 in joint detection of digestive system carcinoma

目的探讨血清中甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)联合检测对消化系统恶性肿瘤的诊断价值。方法采用电化学发光法分别检测200例消化系统恶性肿瘤患者(消化系统恶性肿瘤组)和90例健康体检者(健康对照组)血清中AFP、CEA、CA125、CA199的含量,分析四项肿瘤标志物及其各项肿瘤标志物联合检测对消化系统恶性肿瘤患者的诊断效能。结果四项肿瘤标志物联合检测其敏感性在胃癌、结直肠癌、胰腺癌分别为42.0%、62.0%、82.0%,明显高于单一肿瘤标志物检测,差异有统计学意义(P<0.01),肝癌四项联检的敏感性为82.0%,与AFP单项检测比较差异无统计学意义(P>0.05)。结论除肝癌外,AFP、CEA、CA125、CA199联合检测可提高诊断的敏感性,对消化系统恶性肿瘤的早期诊断具有实用价值。

Objective To explore the serum alpha-fetoprotein （AFP）, carcinoembryonic antigen （CEA）, carbohydrate antigen 125 （CA125）, and carbohydrate antigen 199 （CA199） in the joint detection of digestive system carcinoma. Methods Electrochemiluminescence was applied in the detection of serum AFP, CEA, CA125 and CA199 of 200 cases with digestive system carcinoma （digestive system carcinoma group） and 90 healthy people （health control group）. The diagnostic effects for digestive system carcinoma of the four tumor markers and their joint detection were analyzed. Results The detection sensitivity of the four tumor markers for gastric cancer, colorectal cancer, and pancreatic cancer were 42.0%, 62.0%and 82.0%. These indexes were obviously higher than that of single tumor marker detection, and the difference had statistical significance （P〈0.01）. The detection sensitivity of the four tumor markers for liver cancer was 82.0%, and that had no significant difference with the single detection of AFP. Conclusion Joint detection of AFP, CEA, CA125 and CA199 can improve detection sensitivity except for liver cancer, and it has practical value for the early diagnosis of digestive system carcinoma.