脲类受体酪氨酸激酶抑制剂的研究进展

Recent Advance on Receptor Tyrosine Kinase Inhibitors of Urea

蛋白络氨酸激酶抑制剂作为目前治疗效果明显而且应用前景广阔的抗肿瘤药物备受青睐。本文以近5年的文献为主要参考,对已经上市的和处于研究阶段的脲类酪氨酸激酶抑制剂进行了综述。

Protein tyrosine kinase（ PTK） inhibitors, one of the promising and effective candidates for antitumor drugs, have been attracted much attention in recent years. During the molecular design of the inhibitor, the urea group not only can be the donor and the acceptor of oxygen, but also can prompt the solubility of the compound in water. The achievements of the protein tyrosine kinase inhibitors in last five years were reviewed.