3-芳基-2,5-二甲基吡嗪类化合物的合成

Synthesis of Several 3-Aryl-2,5-Dimethylpyrazines

利用Suzuki偶联反应以2,5-二甲基-3-氯吡嗪及取代苯硼酸为起始原料,合成了吡嗪衍生物,其结构经^1H NMR、IR、EI-MS分析表征。结果表明：在氮气保护条件下,碱性二氧六环中,使用Pd（PPh3）4催化剂,除邻氰基苯硼酸因位阻效应收率较低外,其他产物的收率可达56%-94%。

Suzuki coupling reactions between 2,5-dimethyl-3-chloro-pyrazine and arylboronic acids were achieved for the synthesis of some novel pyrazine derivatives in the presence of Pd（PPh3） 4. All products were characterized and confirmed by ^1H NMR, IR and EI-MS spectra. The results showed that moderate to good yields（56%-94%）were obtained in the oxygen-free basic dioxane under catalysis of Pd（PPh3）4.