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2-溴-4-甲基噻唑-5-甲酸乙酯的合成工艺研究 被引量：2

Study on Synthesis of 2-Bromo-4-methyl-thiazole-5-carboxylic Acid Ethyl Ester
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摘要 以2-氨基-4-甲基噻唑-5-甲酸乙酯（NSIZ）为原料、采用溴化铜为催化剂及溴代剂通过重氮化法合成了2-溴-4-甲基噻唑-5-甲酸乙酯（BSJZ）。确定了反应的优化条件为：反应温度0-5℃,反应时间40 min,物料比n（NSJZ）∶n（H3PO4）∶n（HNO3）∶n（NaNO2）∶n（CuBr2）=1.0∶8.0∶8.0∶1.3∶2.5。优化条件下产品纯度为99.5%,收率达84.7%。 The title compound was synthesized in 84.7% yield（99.5% HPLC） from 2-amino-4-methyl-thiazole-5-carboxylic acid methyl ester（NSJZ）. Copper bromide was applied as the catalyst and also the brominating agent.
作者 吴莹 黄朋勉 唐文娟 陈巨涛
机构地区 长沙理工大学化学与生物工程学院
出处 《精细化工中间体》 CAS 2014年第5期31-33,37,共4页 Fine Chemical Intermediates
基金 长沙市科技局基金项目资助(K1113005-31)
关键词 2-溴-4-甲基噻唑-5-甲酸乙酯 溴化铜 重氮化法 2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester copper bromide diazotization
分类号 R978.5 [医药卫生—药品]
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参考文献9

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共引文献1

同被引文献12

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精细化工中间体
2014年 第5期

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