摘要
以5-氯-3-氯磺酰基-2-噻吩羧酸甲酯为起始物料,经磺酰化、环合及酰胺化等3步反应制得氯诺昔康。目标化合物的结构经1H NMR谱确证。新合成路线短、操作简便,更环保,总收率达56.3%,纯度达99.8%,具有工业化生产前景。
An improved method was designed to synthesize the Lornoxicam in overall yield of 56.3% from 5-chloro-3-chloro-2-thiophene sulfonyl carboxylate by the reactions of sulfonylation, cyclization and amidation. The structure of target compound was identified by ^1H NMR. This method is more simple and environmentally friendly, and suitable for industrial production.
出处
《精细化工中间体》
CAS
2014年第5期38-40,48,共4页
Fine Chemical Intermediates
关键词
氯诺昔康
工艺改进
合成
Lornoxicam
sulfonylation
amidation
carboxylate
