常规抗心力衰竭药物联合螺内酯及培哚普利治疗心力衰竭的疗效分析

Analysis of routine anti heart failure drug therapy combined with spironolactone perindopril in treatment of heart failure

目的调查常规抗心力衰竭药物联合螺内酯及培哚普利治疗心力衰竭的临床疗效。方法选取本院接受治疗的心力衰竭患者112例,随机分为观察组和对照组,每组各56例,对照组患者给予常规治疗联合培哚普利,观察组患者在对照组基础上加用螺内酯,比较两组患者治疗总有效率及治疗后心功能分级情况。结果观察组患者治疗总有效率为96.43%,明显高于对照组(62.5%),差异具有显著性(P<0.05)。治疗后观察组患者心功能分级Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级者分别为24例、17例、10例、5例,对照组分别为3例、14例、13例、26例。观察组明显优于对照组,差异显著(P<0.05)。结论采用常规抗心力衰竭药物联合螺内酯及培哚普利治疗心力衰竭,可显著提高治疗总有效率,明显改善患者心功能。

Objective To investigate the clinical efifcacy of routine anti heart failure drug therapy combined with spironolactone perindopril in treatment of heart failure. Method 112 patients with heart failure in our hospital were selected. They were randomly divided into observation group and control group with 56 patients in each. Control group was given conventional treatment combined with perindopril, while observation group treated based on control group, then combined with spironolactone. The total efifciency and heart functional grade were compared between two groups. Result The total effective rate of observation group was 96.43%, while control group was 62.50%, which showed significant difference （P 〈0.05）, the number of cardiac functional grading forⅠ,Ⅱ,Ⅲ,Ⅳin observation group was 24, 17, 10, 5 cases, respectively;while in control group, they were 3, 14, 13, and 26 cases. The cardiac functional grading of observation group was better than control group, there was signiifcant difference （P 〈0.05）. Conclusion The conventional anti heart failure drug therapy combined with spironolactone perindopril for the treatment of heart failure, can improve the total efifciency and cardiac function in patients.