对比增强CT受检者的肾功能及免疫球蛋白变化

Kidney function and immunoglobulins change in patients who underwent contrast-enhanced CT examination

目的观察对比增强CT(CECT)受检者的肾功能及免疫球蛋白的变化。方法选取34例Child-Pugh分级A期的原发性肝癌患者为研究对象,分别行CECT检查,于检查前及检查后24小时检测尿的相对密度(SG)、pH值及微量白蛋白(MAU),血尿素氮(BUN)、肌酐(SCr)、尿酸(UA)、β2微球蛋白(β2MG)、胱抑素C(Cysc)、C反应蛋白(CRP)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体C3(C3)及补体C4(C4),采用配对t检验进行比较。结果 CECT检查后患者尿pH、MAU及血β2MG显著升高,IgM显著下降(P<0.05),而尿SG及血BUN、SCr、UA、CysC、CRP、IgA、IgG、C3、C4水平变化差异无统计学意义(P>0.05)。结论对比剂可导致尿液碱化、MAU升高及血IgM水平下降。

Objective To study kidney function and immunoglobulins change to the patients who underwent contrast-enhanced CT examination.Methods The study enrolled 34 Child-Pugh class A patients with primary liver cancer who underwent contrast-enhanced CT examination.We examined the level of urine specific gravity（SG）,pH and urine microalbumin（MAU）,and the level of blood urea nitrogen（BUN）,serum creatinine（SCr）,uric acid（UA）,β2 microglobulin（β2 MG）,cystatinC（Cysc）,C-reactive protein（CRP）,immunoglobulin A（IgA）,IgG,IgM,complement C3 （C3 ）and C4 in serum before and after contrast-enhanced CT examination 24 hours,respectively.Results After contrast-enhanced CT examination, the level of pH, MAU and β2 MG were much higher than those before examination,but IgM level reduced significantly （P 〈0.05 ）.However,the changes of SG,BUN,SCr,UA,Cysc, CRP,IgA,IgG,C3 and C4 showed no statistical difference （P 〉0.05）.Conclusion Contrast media can alkalize urine, increase pH and reduce IgM.