肺损伤性毒剂的医学对抗策略研究进展

Progress in study on medical antagonistic strategy against lung-damaging agents

肺损伤性毒剂或肺刺激剂,也称"窒息性毒剂",吸入此类毒剂在临床上均表现为经过一定时间的潜伏期后,迅速发展为急性肺损伤、肺水肿,严重者将导致死亡。近年来,随着对其作用机制研究的深入,国内外开展了不少针对性的防治药物和措施研究。本文从肺损伤性毒剂致病机制、临床对策研究及医学对抗策略三个方面综述了近年来肺损伤性毒剂医学对抗研究的相关进展,以期为临床收治此类毒剂中毒患者提供借鉴。

Inhalation of lung-damaging agents（or lung irritants,choking agents）,such as phosgene etc.,can result in acute lung injury（ALI）,pulmonary edema even death in severe case after a certain latent time. Recently,numerous studies were carried out on some studies on the special or targeted drugs and measures against ALI induced by lung-damage agents,with the research progress on its pathogenesis. This paper will summarized concerned progress in the study on medical antagonistic strategy against lung-damaging agents including its pathogenic mechanism,the treatment trials and medical antagonistic measures on them.