糖尿病肾病患者血清软骨寡聚基质蛋白水平及其与血管钙化的关系

Serum cartilage oligomeric matrix protein and relationship with vascular calcification in diabetic nephropathy patients

目的研究糖尿病肾病(DN)患者血清软骨寡聚基质蛋白(COMP)水平及其与血管钙化的关系。方法收集Ⅳ及Ⅴ期DN患者54例(DN组)及28例健康体检者(对照组),采用ELISA法检测血清COMP水平。根据胸部X线片主动脉弓钙化情况,将DN患者分为无血管钙化组和血管钙化组,比较两组的血清COMP水平。根据合并心血管疾病(CVD)与否,将DN组患者分为合并组和非合并组,比较两组血清COMP水平。采用Logistic回归分析血清COMP水平与血管钙化、CVD发生率之间的关系。结果 DN组患者血清COMP水平高于对照组;DN组主动脉弓钙化者占75.9%,其血清COMP水平高于无血管钙化组;合并CVD组患者血清COMP水平显著高于非合并组(P<0.05);血清COMP水平每升高10ng/mL,血管钙化发生风险增加1.324倍,CVD发生风险增高1.310倍。结论 DN患者血清COMP升高,血管钙化和CVD发生风险增加。

Objective To investigate the level of serum cartilage oligomeric matrix protein（COMP）and its relationship with vascular calcification in diabetic nephropathy（DN）patients.Methods COMP was tested in 54（DN）group and 28 matched healthy persons（healthy group）.DN group was divided into vascular calcification group（VC）and non-vascular calcification（non VC）group.DN group was also divided into cardiovascular disease group（CVD-y）and without cardiovascular disease group（CVD-n）in view of the company of cardiovascular disease.Serum COMP levels was compared between the DN group and the control group,the VS group and the non VS group,and the CVD-y group and the CVD-n group.The correlations between COMP level and the occurrence of cardiovascular disease,the incidence of vascular calcification were estimated by Wald analysis of the application of Wald test.Results Serum COMP in DN group was significantly higher than the control group;Aortic arch calcification accounted for75.9% of the DN group.The serum COMP in VC group was higher than that of non VC group,CVD-y group had higher COMP than CVD-n group old respectively with every 10ng/mL increased in concentration of serum COMP.Conclusion The higher of concentration of serum COMP,the more risk of vascular calcification and CVD.