高迁移率蛋白A2和血管内皮生长因子在膀胱癌中的表达及意义

The expression and significance of HMGA2 and VEGF in tumorigenesis and recurrence of bladder urothelial carcinoma

目的研究高迁移率蛋白A2(HMGA2)和血管内皮生长因子(VEGF)在膀胱尿路上皮癌中发生及复发中的表达及其意义。方法应用免疫组织化学技术检测63例膀胱尿路上皮癌组织中HMGA2和VEGF的表达,其中复发膀胱尿路上皮癌21例。结合临床病理资料进行统计学分析。结果 63例膀胱癌标本中HMGA2和VEGF的表达明显升高,与膀胱癌组织的病理分级、临床分期及复发有关,且HMGA2和VEGF的表达呈正相关,差异有统计学意义(P<0.05)。与未复发组相比,21例复发膀胱尿路上皮癌中HMGA2和VEGF的表达明显升高(P<0.05)。复发膀胱尿路上皮癌中HMGA2与VEGF的表达呈正相关。结论 HMGA2与VEGF在膀胱尿路上皮癌中表达增高,与膀胱尿路上皮癌的复发和转移密切相关。

[ Objective ] To investigate the expression and the significance of HMGA2 and VEGF in the develop- ment and recurrence of bladder urothelial carcinoma. [Methods] 10 cases of normal bladder tissues were treated as a control. The immunohistochemistry technique was used to analyze the expression of the HMGA2 and VEGF in 63 bladder urothelial carcinoma combined with the clinical data. In 21 eases of recurrent bladder urothelial carcinoma tissues, the expression of the HMGA2 and VEGF was also investigated. [Results] We confirmed that the expression of the HMGA2 and VEGF in the 63 cases of bladder urothelial carcinoma increased significantly, and it was related with the pathological grade, clinical stage and recurrence （P 〈0.05）. There was a positive correlation between HMGA2 and VEGF. Likewisely, HMGA2 and VEGF in the 21 recurrent cases increased significantly compared with the control group （P 〈0.05）. [ Conclusion ] The expression of HMGA2 and VEGF was elevated in the bladder urothelial carcinoma. They are closely related with the recurrence and tumorigenesis of bladder urothelial carcinoma.