肺泡灌洗液中细胞因子联合检测在ARDS中的临床意义

Clinical significance of combined detection of cytokines in bronchoalveolar lavage fluid of patients with ARDS

目的观察急性呼吸窘迫综合征(ARDS)患者肺泡灌洗液中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平在血必净治疗前后的变化。方法选择我院住院的ARDS患者44例,随机分为两组,每组22例,对照组给予常规治疗,实验组在常规治疗上加用血必净,两组在治疗前、治疗后7天及治疗后14天检测肺泡灌洗液中IL-6、IL-8及TNF-α的水平变化。结果两组患者肺泡灌洗液促炎因子IL-6、IL-8及TNF-α水平在治疗前无统计学差异(P>0.05)。治疗后7天及治疗后14天,实验组的IL-6、IL-8及TNF-α水平明显低于对照组(P<0.05)。结论肺泡灌洗液中IL-6、IL-8联合TNF-α水平的检测对评估ARDS患者病情的严重程度及监测治疗结果、评估预后结果有一定参考价值。

Objective To observe the changes of IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid of patients with ARDS patients treated with Xuebijing. Methods 44 patients with ARDS were randomly divided into 2 groups, the experimental group （22 cases） and the control group （22 cases）. All patients were given routine treatment, and the experimental group was additionally treated with Xuebijing. The levels of IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid were detected before and 7 and 14 days after the treatment in the two groups. Results The levels of IL-6, IL-8 and TNF-α had no significant difference in the two groups before the treatment （ P 〉 0.05 ）, but they were obviously lower in the experimental group than in the control group 7 and 14 days after the treatment （ P 〈 0.05 ）. Conclusion The combined detection of IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid has a certain significance on the evaluation and prognosis of ARDS patients.