三磷酸腺苷二钠氯化镁治疗支气管肺炎所致心肌受损的疗效观察

Clinical observation of adenosine disodium triphosphate and magnesium chloride in the treatment of children with myocardial injury induced by bronchopneumonia

目的观察三磷酸腺苷二钠氯化镁治疗支气管肺炎所致心肌受损的临床疗效。方法将172例支气管肺炎并发心肌受损患儿随机分为观察组78例和对照组94例,两组均抗感染及对症支持等常规治疗,观察组用三磷酸腺苷二钠氯化镁营养心肌,对照组用二磷酸果糖营养心肌,疗程均为1周。比较两组患儿治疗前后CK-MB及cTnl的变化。结果治疗1周后,CK-MB和cTnl的检测值较治疗前均降低,但观察组降低更显著(P<0.01);CK-MB和cTnl的阳性率较治疗前均降低,两组相比,CK-MB的阳性率差异无统计学意义(P>0.05),而cTnl的阳性率差异有统计学意义(P<0.05)。结论三磷酸腺苷二钠氯化镁治疗支气管肺炎所致心肌受损,疗效好。

Objective To observe the therapeutic effect of adenosine disodium triphosphate and magnesium chloride in the treatment of children with myocardial injury induced by bronchopneumonia. Methods 172 children with myocardial injury induced by bronchopneumonia were randomly divided into two groups. All children were given antibiotics and the conventional treatment. 78 cases as the experimental group were given adenosine disodium triphosphate and magnesium chloride for injection additionally. 94 cases as the control group were given sodium fructose diphosphate for injection additionally. The data of CK-MB and cTnl were compared between the two groups after one week. Results 1 week after the treatment, the value of CK-MB and cTnl reduced in the two groups, and the decrease was more pronounced in the experimental group than in the control group （ P 〈 0. 01 ）. The positive rate of CKMB and cTnl reduced in the two groups, but there was no significant difference in the positive rate of CK-MB between the two groups （P 〉 0. 05）. The positive rate of cTnl was obviously lower in the experimental group than in the control group （P 〈 0. 05）. Conclusion The treatment of adenosine disodium triphosphate and magnesium chloride in children with myocardial injury induced by bronchopneumonia is safe and effective.