热疗联合胸腔内化疗治疗恶性胸腔积液的临床研究

Clinical study of hyperthermia combined with intra-pleural chemotherapy in the treatment of malignant pleural effusion

目的观察热疗联合胸腔内化疗治疗癌性胸腔积液的疗效。方法 63例确诊为癌性胸腔积液患者随机分两组:对照组31例接受中心静脉置管抽液后单纯胸腔内灌注化疗药物;研究组32例给予置管抽液后灌注化疗药物治疗及热疗。比较两组患者的临床症状改善状况、生活质量及不良反应。结果研究组胸水治疗有效率明显高于对照组(87.5%vs 64.5%,P<0.05),生活质量的改善率亦明显好于对照组(93.8%vs66.7%,P<0.01)。两组毒性反应率比较无统计学差异(P>0.05)。结论热疗及胸腔灌注化疗联合治疗癌性胸腔积液的疗效显著,不良反应未增加。

Objective To study the curative effect of hyperthermia combined with intra-pleural chemotherapy in the treatment of malignant pleural effusion. Methods 63 with malignant pleural effusion were randomly divided into two groups. The control group （31 cases） received central venous drainage with chest internal chemotherapeutic drugs. The study group （32 cases） was treated with intra-pleural catheter drainage after chemotherapy combined with hyperthermia. The clinical symptoms, the improvement of quality and adverse reactions were compared between the two groups. Results The effective rate was higher in the study group than in the control group. The quality of life was significantly better in the study group than in the control group. The toxicity of the two groups had no statistical difference. Conclusion Hyperthermia and pleural infusion combined with chemotherapy has significantly curative effect in the treatment of malignant pleural effusions, with less adverse reactions.