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microRNAs与COPD的研究进展 被引量：3

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摘要 COPD是一种具有气流受限特征的疾病,气流受限不完全可逆,呈进行性发展,与肺部对有害气体或有害颗粒的异常炎症反应有关。COPD患病率和死亡率呈上升趋势。至2007年COPD已成为全球第四大死亡原因,目前普遍认为COPD以气道、肺实质和肺血管的慢性炎症为特征,在肺的不同部位有肺泡巨噬细胞、T淋巴细胞（尤其是CD8^＋）和中性粒细胞增加,部分患者有嗜酸性粒细胞增多。
作者 罗婷 江涛
机构地区 重庆医科大学附属第一医院呼吸科
出处 《临床肺科杂志》 2015年第1期145-147,共3页 Journal of Clinical Pulmonary Medicine
关键词 MICRORNAS COPD 嗜酸性粒细胞增多 肺泡巨噬细胞 气流受限 T淋巴细胞 炎症反应 有害气体
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献15

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同被引文献40

  • 1慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中国医学前沿杂志（电子版）,2014,6(2):67-80. 被引量：2042
  • 2Severine Letuve, Alexander Kozhich, Nassim Arouche, et at. ~KL- 40 Is Elevated in Patients with Chronic Obstructive Pulmonary Dis- ease and Activates Alveolar Maerophages [ J 1- The Journal of Im- munology, 2008, 181:5167-5173.
  • 3Maria RosedOlia de Moraes, Adeliane Castro da Costa, Krislainy de Sousa Corr~a,et at. Interleukin-6 and interleukin-8 blood levels' poor association with the severity and clinical profile of ex-smokers with COPD[ J]. International Journal of COPD,2014,9:735 -743.
  • 4Aziz Gumus, Servet Kayhan, Halit Cinarka, et at. High Serum YKL- 40 Level in Patients with COPD Is Related to Hypoxemia and Dis- ease Severity[J]. Tohoku J. Exp. Med,2013,229:163 - 170.
  • 5Lee CG, Da Silva CA, Dela Cruz CS, et al. Role of chitin and chitinase/chitinase-like proteins ininflammation, tissue remode- ling, and injury[ J]. Annu Rev Physiol,2011,73 :479 - 501.
  • 6Stefano Guerra, Marilyn Halonen, Duane L. Sherrill, et al. The re- lation of circulating YKL-40 to levels and decline of lung function in adult life[ J~. Respiratory Medicine,2013,107 : 1923 - 1930.
  • 7Arjun K Ravi, Shruti Khurana, Jonathan Lemon, et al. Increased levels of soluble interleukin-6 receptor and CCL3 in COPDsputum [ J ]. Respiratory Research,2014,15 : 103 - 113.
  • 8Simonetta Baldi,Paul Ejose, Claudio Bruschi, et al. The mediating role of cytokine IL-6 on the relationship of FEV1 upon 6-minute walk distancein chronic obstructive pulmonary disease[ J ]. Interna- tional Joumal of COPD,2014,9:1091 - 1099.
  • 9Allan Klitgaard S rensen, Dennis Back Holmgaard, Lone Hagens Mygind, et al. Neutrophil-to-lymphocyte ratio, calprotectin and YKL-40 in patients with chronic obstructive pulmonary disease: correlations and 5-year mortality-a cohort study[J]. Journal of In- flammation, 2015,12 : 20 - 32.
  • 10Dennis B Holmgaard, Lone H Mygind, Ingrid L Titlestad, et al. Plasma YKL~-0 and all-cause mortality in patients with chronic ob- structive pulmonary disease[J]. BMC Pulmonary Medicine,2013, 13:77 - 87.

引证文献3

二级引证文献24

临床肺科杂志
2015年 第1期

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