雷美替胺关键中间体2-(2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-基)丙烯酸乙酯的合成
Synthesis of Ramelteon intermediate Ethyl 2-(6,7-dihydro-1H-inden-and[5,4-b]furan-8(2H)-ylidene) acetate
摘要
通过串联的C-H活化Heck反应和分子内迈克尔加成,我们完成了一种雷美替胺的关键中间体2-(2,6,7,8-四氢-1H-茚并[5,4-b]呋喃-8-基)丙烯酸乙酯的合成。
An synthesis of Ramelteon intermediate Ethyl 2-（6,7-dihydro-1H-inden- and[5,4-b]furan-8（2H） -ylidene） acetate has been achieved, which involved a tandem C-H activation-alkylation/Heck reac-tion and subsequent highly intramolecular Michael addition to generate the corresponding intermediate.
出处
《化工时刊》
CAS
2014年第10期9-12,共4页
Chemical Industry Times
参考文献4
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