急性冠脉综合征患者血清cTnI和hs-CRP水平的变化及其临床意义

The Level Variation of Serum cTnI and hs-CRP in Actue Coronary Syndrome Patients and Its Clinical Significance

目的:测定急性冠脉综合征(ACS)患者血清的肌钙蛋白I(cTnI)和超敏C反应蛋白(hs-CRP)的含量并评价其临床价值。方法:选择临床诊断为ACS的患者135例,其中急性心肌梗死(AMI)42例,不稳定型心绞痛(UAP)54例,稳定型心绞痛(SAP)39例,60例健康体检作为对照组,分别检测其cTnI和hs-CRP的含量,并作相互比较。结果:急性冠脉综合征(ACS)患者(包括AMI、UAP、SAP)cTnI、hs-CRP含量明显高于对照组;AMI组的cTnI、hs-CRP的含量比UAP的均显著升高(P<0.05);UAP组的cTnI、hs-CRP含量也高于SAP组,差异有显著性(P<0.05)。结论:血清cTnI、hs-CRP水平与ACS发生、发展有着密切联系,它们与冠状动脉病变程度密切相关,二者可作为ACS发病及判断其严重程度的重要血清标志物。

Objective：To measure the contents of actue coronary syndrome（ACS）patients＇ serum cardiac troponin I（cTnI）and high sensitive C reactive protein（hs-CRP）and to evaluate their clinical value.Methods：Clinical diagnosis of135 patients with ACS,including acute myocardial infarction（AMI）in 42 patients,unstable angina pectoris（UAP）54cases,stable angina pectoris（SAP）in 39 cases,60cases of healthy as the control group,the content of cTnI and hsCRP were measured,and compared with each other.Results：The levels of cTnI and hs-CRP in ACS patients（including AMI,UAP,SAP）were apparently higher than those of controls＇;contents of cTnI and hs-CRP in AMI group go notably higher than those in UAP（P〈0.05）;meanwhile,contents of cTnI and hs-CRP in UAP group were also higher than those in SAP（P〈0.05）.Conclusion：The serum levels of cTnI and hs-CRP are closely correlated with the occurrence and development of ACS.They are closely related to the lesions of coronary arteries.They are important serum makers of the attack and serve degree of ACS respectively.