心脏机械瓣膜置换术后早期二种抗凝模型的比较研究

A Comparative Study of Early Postoperative Anticoagulation Model Two Mechanical Heart Valve Replacement

目的:建立连云港地区心脏机械瓣膜置换术后早期华法林抗凝模型。方法:收集我院2010年9月-2013年9月心脏机械瓣膜置换手术采用华法林抗凝的患者,随机分为两组,起始剂量3.75mg组(A组)和起始剂量5mg组(B组),进行对比研究。比较两组抗凝起始剂量、维持剂量、抗凝强度、术后到达抗凝达标时间、抗凝稳定时间、术后抗凝并发症等。结果:A、B组抗凝模型均取得良好的抗凝结果;相比而言,B组模型比A组模型更有利于抗凝达标和稳定,抗凝并发症发生率比较无明显差别。结论:建立心脏机械瓣膜置换术后早期华法林抗凝模型,降低抗凝并发症发生率,从而降低医疗费用,改善患者长期生活质量。

Objective：Established early in Lianyungang warfarin model mechanical heart valve replacement surgery.Methods：Collected in our hospital in September 2010 to September 2013 mechanical heart valve replacement surgery patients using warfarin were randomly divided into two groups,the starting dose of 3.75 mg group（A）and the starting dose of 5mg group（group B）,comparative study.Starting dose anticoagulation were compared,the maintenance dose,anticoagulation intensity,postoperative anticoagulation reach compliance time,stable anticoagulation,postoperative anticoagulation complications.Results：A,B group anticoagulant models have achieved good results anticoagulation;contrast,group B than in group A model anticoagulant standard model and more conducive to stable anticoagulation was no significant difference in the incidence of complications.Conclusion：A,B group anticoagulant models have achieved good results anticoagulation;contrast,group B than in group A model anticoagulant standard model and more conducive to stable anticoagulation was no significant difference in the incidence of complications.