血清NSE、CA125及β2-MG测定对非霍奇金淋巴瘤疗效及预后判断的价值

Values of NSE,CA125 and β2-MG for Judgement of Effect and Prognosis in Non-Hodgkin Lymphoma

目的:探讨NHL患者血清NSE、CA125及β2-MG水平对判断临床疗效和预后的价值。方法:测定46例NHL患者化疗前、后血清NSE、CA125及β2-MG,分析其与临床疗效和3年生存率的相关性。结果:(1)血清NSE增高患者化疗有效率、3年生存率低于血清NSE正常患者,差异有统计学意义(P<0.05);其中化疗有效患者化疗后血清NSE水平较化疗前明显降低,差异有统计学意义(P<0.05)。(2)血清CA125增高患者化疗有效率、3年生存率低于血清CA125正常患者,差异有统计学意义(P<0.05);化疗有效患者化疗后血清CA125水平较化疗前明显降低,差异有统计学意义(P<0.05)。(3)血清β2-MG增高患者化疗有效率低于血清β2-MG正常患者,差异有统计学意义(P<0.05);血清β2-MG增高患者与正常患者3年生存率比较,差异无统计学意义(P>0.05);化疗有效患者化疗后血清β2-MG水平较化疗前明显降低,差异有统计学意义(P<0.05)。结论:NHL患者血清NSE、CA125及β2-MG水平与化疗敏感性及临床预后密切相关,对判断疗效和预后有重要价值。

Objective：To research the values of NSE,CA125 and β2-MG for judgement of effect and prognosis in nonHodgkin lymphoma.Methods：The data of 46 patients with NHL were retrospectively analysed,the relationships between NSE,CA125 and β2-MG activities and the effect of treatment as well as prognosis were studied.Results：（1）The chemotherapy efficacy and three-year survival rate of patients with increased NSE were signifecantly lower than that of patients with normal NSE（P〈0.05）;the NSE level of patients with positive response was signifecantly lower than that of patients with negative response in group with increased NSE（P〈0.05）.（2）The chemotherapy efficacy and threeyear survival rate of patients with increased CA125 were signifecantly lower than that of patients with normal CA125（P〈0.05）;the CA125 level of patients with positive response was signifecantly lower than that of patients with negative response in group with increased CA125（P〈0.05）.（3）The chemotherapy efficacy of patients with increased β2-MG were signifecantly lower than that of patients with normal β2-MG（P〈0.05）;there was no difference in three-year survival rate between patients with increased β2-MG and patients with normal β2-MG;the β2-MG level of patients with positive response was signifecantly lower than that of patients with negative response in group with increased β2-MG（P〈0.05）.Conclusion：The levels of NSE,CA125 and β2-MG are useful for the judgment of severity,response to treatment and prognosis of NHL.