丙型肝炎与甲状腺疾病的相关性研究

Related Factors Research of Hepatitis C Complicated with Thyroid Disease

目的：探讨丙型肝炎病毒（HCV ）感染并发甲状腺疾病的相关因素。方法：回顾性分析2003年1月-2014年6月期间在我院诊治的1996例慢性肝炎感染者的临床资料。结果：性别、情绪、干扰素治疗时间和甲状腺自身抗体是HCV感染并发甲状腺疾病的主要影响因素。女性（OR＝6．801，95％ CI：2．051～22．108）、干扰素治疗时间长（OR＝7．942，95％ CI：4．502～31．018）、不良情绪（OR＝1．702，95％ CI：1．319～2．296）和甲状腺自身抗体阳性（OR＝9．056，95％ CI：1．516～12．071）等四项因素和HCV感染并发甲状腺疾病密切相关，为其独立危险因素。结论：丙肝感染者的性别、使用干扰素、不良情绪和甲状腺自身抗体阳性是诱发甲状腺疾病的主要影响因素。

Objective：To study related factors of hepatitis C virus （HCV） infection complicated with thyroid disease . Methods：The clinical data of 1 996 cases of chronic hepatitis infections diagnosed and treated in the hospital during the period of January 2003 to June 2014 were retrospectively analyzed .Results：Gender ,emotion ,interferon treatment time and thyroid autoantibodies are main influencing factors of HCV infection complicated with thyroid disease .Four fac-tors ,female （OR= 6 .801 ,95% CI：2 .051~22 .108） ,interferon treatment time is long （OR=7 .942 ,95% CI：4 .502~31 .018） ,adverse emotions （OR=1 .702 ,95% CI：1 .319~2 .296） and positive thyroid autoantibodies （OR= 9 .056 , 95% CI：1 .516~12 .071） were closely related to and HCV infection complicated with thyroid disease and were inde-pendent risk factors for it .Conclusion：Hepatitis C infection patients’gender ,the use of interferon ,bad mood ,and thy-roid autoantibodies positive are the main influence factors inducing thyroid disease .