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OSAHS并肺动脉高压的危险因素分析 被引量:8

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摘要 目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并肺动脉高压(PAH)的危险因素。方法对120例OSAHS患者进行超声心动图检查,以肺动脉收缩压(s PAP)≥36 mm Hg为界值,分为PAH组和单纯组,分析两组患者的一般情况、肺功能、多普勒超声心动图、多导睡眠监测(PSG)结果,采用生活质量自评量表(SF-36)对生活质量进行评价。以肺动脉收缩压作为应变量,以BMI、吸烟指数、最低血氧饱和度(LSa O2)、TST-Sp O2<90%、TST-A、睡眠呼吸暂停低通气指数(AHI)、夜间平均Sp O2为协变量,进行多因素Logistic回归分析。结果 120例OSAHS患者中PAH 34例(28.3%),PAH的发生与患者年龄、性别无关。PAH组与单纯组BMI分别为(31.22±6.43)、(25.78±10.41)kg/m2,吸烟指数分别为(17.35±7.50)、(8.77±5.24)包/a,SF-36评分分别为(56.64±6.47)、(64.88±10.53)分,两组比较,P均<0.05。PAH组及单纯组中重度OSAHS发生率分别为85.2%(29/34)、10.4%(9/86),两组比较,P<0.05。两组夜间均存在明显低氧血症,PAH组与单纯组AHI分别为(48.38±10.73)、(32.41±8.02)次/h,TST-A分别为23.01%±13.44%、9.28%±3.29%,氧减指数分别为(41.96±15.32)、(32.81±12.33)次/h,TST-Sp O2<90%分别为20.24%±9.81%、9.82%±5.05%,LSa O2分别为67.4%±9.28%、75.40%±11.02%,平均Sp O2分别为(89.11±18.9)、(93.72±9.87)mm Hg,两组比较,P均<0.05。Logistic回归分析提示BMI、夜间平均Sp O2、TST-A为OSAHS并PAH的独立危险因素。结论 OSAHS并PAH患者中重度OSAHS发生率高,生活质量进一步下降;BMI、夜间平均Sp O2、TST-A为OSAHS并PAH的独立危险因素。
出处 《山东医药》 CAS 2014年第39期53-55,共3页 Shandong Medical Journal
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参考文献13

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二级参考文献53

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