纳秒脉冲电场对中成药灭菌效果的初步考察

Preliminary Research on Sterilization Effect of Chinese Patent Medicine by Nanosecond Pulsed Electric Fields

目的:考察纳秒脉冲电场对不同剂型中成药的灭菌效果。方法:选择大山楂丸、舒心糖浆、益母草膏3种典型的中成药为研究对象,场强选择40,50,60 k V·cm-1,脉冲数10,100次,通过2个参数交互作用,采用纳秒脉冲电场发生器对中成药进行电击处理,利用平皿法检查灭菌效果。结果:在选定的参数条件下,该法对大山楂丸细菌的灭菌无效,对舒心糖浆和益母草膏灭菌合格。结论:纳秒脉冲电场对液体和半固态中成药制剂灭菌效果较好。

Objective： To investigate sterilization effect on Chinese patent medicine by nanosecond pulsed electric fields. Method： Taking Dashanzha pills, Shuxin syrup and Yimucao pastes as research objects, field strength was 40, 50, 60 kV ·cm^-1 and pulse frequency was 10, 100 times, by interaction of these two parameters, Chinese patent medicine was electric shocked by nanosecond pulsed electric fields generator, sterilization effect was detected by plating method. Result： Sterilization by nanosecond pulsed electric fields was effective to Shuxin syrup and Yimucao pastes while invalid to Dashanzha pills. Conclusion： Sterilization is effective to liquid and semi-solid Chinese patent medicine by nanosecond pulsed electric fields.