线粒体靶向递药系统的研究进展

Research Advance in Mitochondrial Targeting Drug Delivery System

线粒体控制着细胞凋亡的激活系统。肿瘤细胞的多种特征,包括无限的增殖能力、对抑制生长信号的不敏感、受损的细胞凋亡机制等都与线粒体的机能丧失有关。研究发现,肥胖、糖尿病等疾病的发生发展过程中均存在线粒体功能的紊乱,并且多种疾病的发生与线粒体DNA的变异有关。因此,为了防止或修复线粒体功能的损伤,寻找靶向线粒体的递药系统越来越重要。针对线粒体的结构特征,该文综述了国内外不同线粒体靶向策略的研究进展。

Mitochondria controls the activation system of apoptosis,a variety of characteristics of tumor cells,including unlimited proliferation ability,unsensitive to the signals of growth inhibition and the damaged apoptosis mechanism,are related to the function loss of mitochondria. Some researches found that the mitochondrial function disorder exists in the occurrence and development of some diseases,such as obesity and diabetes, and the occurrences of many diseases have a relationship with the DNA mutation of mitochondria.Therefore,in order to prevent or repair the damaged function of mitochondrion,looking for the drug delivery systems targeting mitochondria is more and more important. Aiming at the mitochondrial structure characteristics,this paper reviews the research advances in different mitochondrial targeting strategies at home and abroad.