母牛分枝杆菌菌苗辅助治疗结核性多浆膜腔积液47例疗效观察

Observation on Mycobacterium Vaccae Vaccine in Adjuvant Treatment of Tuberculous Polyserositis in 47 Cases

目的观察母牛分枝杆菌菌苗辅助抗结核治疗结核性多浆膜腔积液的疗效。方法将96例结核性多浆膜腔积液患者按随机分组方法分为观察组47例和对照组49例,两组均采用3HREZ/15HRE方案进行抗结核治疗,观察组在此基础上加用母牛分支杆菌菌苗肌肉注射。结果观察组治愈32例(68.09%),有效13例(27.66%),无效2例(4.26%);对照组治愈20例(40.82%),有效20例(40.82%),无效9例(18.36%)。观察组治愈率明显高于对照组(P<0.05)。结论在传统抗结核药物治疗结核性多浆膜腔积液的基础上,联合使用母牛分枝杆菌菌苗,疗效明显优于单纯的传统抗结核药物治疗。

Objective To observe the effect of Mycobacterium vaccae vaccine in auxiliary anti- tuberculosis treatment of tuberculous polyserositis. Methods 96 cases of tuberculous polyserositis were randomized divided into the observation group（ 47 cases） and the control group（ 49 cases）. The two groups were treated by the 3HREZ / 15 HRE anti- tuberculosis treatment schemes. On this basis the observation group was add with Mycobacterium vaccae vaccine by intramuscular injection. Results Among 47 cases in the observation group,32 cases（ 68. 09%） were cured,13 cases（ 27. 66%） were effective and 2 cases（ 4. 26%） were ineffective; among 49 cases in the control group,20 cases（ 40. 82%） were cured,20 cases（ 40. 82%） were effective and 9 cases（ 18. 36%） were ineffective,the cure rate of the observation group was significantly higher than that of the control group with statistical difference（ P〈0. 05）. Conclusion The combination use of Mycobacterium vaccae vaccine and the traditional anti- tuberculosis drugs has significantly better effect than the traditional anti- tuberculosis drugs alone for treating tuberculous polyserositis.