淫羊藿苷对酒精致小鼠骨髓细胞微核率的影响

Effects of icariin on micronucleus rate of bone marrow cell in alcohol- treated mice

目的:观察淫羊藿苷对酒精灌胃小鼠骨髓嗜多染红细胞(PCE)微核率的影响,探讨淫羊藿苷对酒精所致小鼠遗传物质损伤的保护作用。方法:健康成年雄性昆明小鼠30只,随机分为对照组、模型组(单纯酒精灌胃)和给药组(酒精+淫羊藿苷灌胃),每组10只。给小鼠连续灌胃5周,取其股骨检测骨髓嗜多染红细胞微核率。结果:淫羊藿苷能显著降低酒精组小鼠骨髓细胞微核率,与对照组比较差异具有统计学意义(P<0.01)。结论:淫羊藿苷对酒精致小鼠骨髓嗜多染红细胞微核(MN)具有一定的保护作用。

Objective：To observe effects of icariin on micronucleus rate of bone marrow PCE cell in alcohol-treated mice, and to explore the protective effect of icariin on genetic material damage in alcohol-treated mice. Methods：30 adult male mice were randomly divided into normal group, model group and treated group with 10 mice in each group. Animal model was made by gavage with alcohol for five weeks. Treated group was made by gavage with alcohol and icariin at the same time for five weeks. The normal group was given distilled water. The mice were killed and bone marrow smear were made. The micronucleus rate of bone marrow PCE cell was determined. Results：The icariin could reduce the micronucleus rate of bone marrow PCE cell in alcohol-treated mice significantly （P〈0. 01）. Conclusions：The icariin has protective effects on micronucleus of bone marrow cell in alcohol-treated mice.