巨细胞病毒感染婴幼儿肝功能相关指标分析探讨

Analysis and exploration of related liver function indices in infants and young children with cytomegalovirus infections

目的:探讨丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(GGT)及总胆红素(TBIL)生化指标在巨细胞病毒(HCMV)感染婴幼儿中有无肝细胞损伤的参考价值。方法:检测134例巨细胞病毒感染患儿和50例非巨细胞病毒感染患儿的HCMV-IgM、ALT、AST、GGT和TBIL各项指标,用SPSS17.0对所测结果进行统计分析。结果:巨细胞病毒感染组ALT、AST、GGT、TBIL均比对照组高,差异有统计学意义(P<0.05)。结论:ALT、AST、GGT和TBIL升高对判断巨细胞感染是否有肝功能损伤有一定的参考价值,提示治疗时应注意保肝治疗。

Objective：To explore the reference value of alanine aminotransferase （ ALT） , aspartate aminotransferase （ AST） ,γ-glutamyl transpeptidase （ GGT） and total biIirubin （ TBIL） in judging the liver injury of human cytomegalovirus （ HCMV） infected infants and young children. Methods：HCMV-IgM, ALT, AST, GGT and TBIL in 134 cases with cytomegalovirus infections （ HCMV infected group） and 50 cases without cytomegalovirus infections （ control group） were detected. The results were statistically analyzed with SPSS17. 0. Results：The levels of ALT, AST, GGT and TBIL in HCMV infected group were significantly higher than those in control group, and the differences were statistically significant （P〈0. 05）. Conclusions：ALT, AST, GGT and TBIL have a certain reference value in judging the liver injury of children infected with HCMV, which indicates that more attention should be paid to liver-protecting therapy in HCMV infection.