急性缺血性脑卒中患者血清S100B蛋白含量变化的意义

SERUM S100B CHANGES OF PATIENTS WITH ACUTE ISCHEMIC STROKE

目的探讨急性缺血性脑卒中(AIS)患者血清S100B蛋白水平变化及其意义。方法回顾性对照分析62例AIS患者、30名正常对照者血清S100B蛋白的含量,比较AIS患者在不同病情、梗死面积时血清S100B蛋白水平变化。结果AIS患者血清S100B蛋白[(0.32±0.07)μg/L]浓度明显高于正常对照组[(0.15±0.02)μg/L](p<0.01)。神经功能缺损程度评分的增高,血清S100B水平亦明显升高。结论血清S100B蛋白水平可作为急性脑卒中患者病情判断及预后评估指标。

Objective To explore the changes and significance of serum S100B protein content in patients with acute ische- mie stroke. Methods The content of serum S100B in 62 patients with AIS and 30 normal control were measured. The changes of SIOOB were compared with patients of different pathogenetic condition and infarction size. Results The level of serum S100B in pa- tients with AIS increased significantly compared with control group （p 〈0. 01 ）. The level of serum S100B increased with the score of neural function detection and infarction area. Conclusions The S100B protein can be one of the index to predict the neural function and outcome of AIS.