两种药物联合治疗对糖尿病周围神经病变患者神经传导速度及血流变学的影响

Influence of two-drug combination therapy on nerve conduction velocity and hemorheology in patients with diabetic peripheral neuropathy

目的探讨丹参川穹嗪联合甲钴胺对糖尿病周围神经病变患者神经传导速度及血流变学的影响。方法将84例糖尿病周围神经病变患者随机分成观察组与对照组,每组42例。两组患者均严格控制血糖,观察组患者给予丹参川穹嗪联合甲钴胺静脉滴注治疗,对照组给予甲钴胺静脉滴注治疗,两组疗程均为4周。观察两组患者临床疗效、神经传导速度及血流变学的变化。结果观察组患者总有效率、感觉正中神通经、腓神经传导速度、运动正中神经、腓神经传导速度、血管内径变化率明显高于对照组;空腹血糖、总胆固醇(TC)、三酰甘油(TG)、血浆黏度、高切黏度、低切黏度、收缩期血管峰值血流速度(PSV)、内膜中层厚度(IMT)、管径狭窄率均明显低于对照组(P<0.05)。结论丹参川穹嗪联合甲钴胺治疗糖尿病周围神经病变患者临床疗效明显,有效提高神经传导速度,改善血液流变学状态。

Objective To study the influence of Danshen ligustrazin combined with mecobalamine on the nerve conduction velocity and hemorheology in the patients with diabetic peripheral neuropathy.Methods 84 patients with diabetic peripheral neuropathy were divided into the observation group and the control group,42 cases in each group.The blood sugar in the two group was strictly controlled.The observation group was given Danshen ligustrazin combined with mecobalamine by intravenous drip,while the control group was given intravenous drip of mecobalamine with the treatment course of 4weeks.The clinical efficacy and the change of nerve the conduction velocity and hemorrheology were observed in the two groups.Results The total effective rate,conduction velocity of median and peroneal sensory nerve,conduction velocity of median and peroneal motor nerve and change rate of blood vessel diameter in the observation group were significantly higher than those in the control group;while fasting blood glucose,TC,TG,plasma viscosity,high shear viscosity,low shear viscosity,PSV,IMT and diameter stenosis rate were significantly lower than those in the control group（P〈0.05）.Conclusion Danshen ligustrazin combined with mecobalamine has distinct clinical effect for treating diabetic peripheral neuropathy,effectively increase the nerve conduction velocity and improve the hemorheologic state.