原发性干燥综合征B细胞亚群与疾病活动性的相关性分析被引量：6

Correlation between B lymphocytes subsets and disease activity of primary Sjogren's syndrome

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摘要目的探讨原发性干燥综合征(primary Sjgren's syndrome,PSS)患者外周血B细胞亚群的分布与疾病活动性的相关性。方法我科住院治疗的68例初次诊断原发性PSS患者,检测外周血CD19+Ig D+B细胞比例,计算PSS疾病活动指数(ESSDAI)和唇腺浸润灶指数(FS),分析患者CD19+Ig D+B细胞亚群与患者疾病活动的相关性。结果 CD19+Ig D+B细胞比例与疾病活动指数呈正相关(r=0.662,P<0.05)。FS阳性患者CD19+Ig D+B细胞比例明显高于FS阴性患者(P<0.05)。结论 CD19+Ig D+B细胞亚群与病情活动密切相关,其比例增高提示患者疾病处于高活动状态,可为原发PSS疾病活动及治疗效果评价的敏感指标。 Objective To investigate the association of peripheral blood B lymphocytes subsets with activity of primary Sjogren＇s syndrome（PSS）. Methods Sixty-eight hospitalized PSS patients in our department were involved in the study. We measured the ratio of peripheral blood CD19＋IgD＋B cell, calculated EULAR Sjogren＇s syndrome （SS）Disease Activity Index（ ESSDAI） and focus score,and analyzed the correlation between CD19＋IgD＋B cell subset and activity of the disease. Results The ratio of CD19＋IgD＋B lymphocytes subsets was positively correlated with the activity of the disease（ r = 0. 662 ,P 〈 0. 05 ）. The ratio of CD19＋IgD＋B lym- phocytes subsets in FS positive patient was significantly higher than that in FS negative patients（P 〈 0. 05 ）. Conclusion CD19＋IgD ＋B lymphocytes subsets are closely associated with the activity of the disease. An increase in the ratio of B lymphocytes suggests the high active state of the disease. Thus, it can be used as a sensitive index to evaluate the disease activity and effect of treatment.

作者杨静邓代华邹晋梅张羽田岚李思吟

机构地区四川省绵阳市中心医院风湿科

出处《实用医院临床杂志》 2014年第6期70-72,共3页 Practical Journal of Clinical Medicine

关键词原发性干燥综合征 B细胞亚群疾病活动 Primary sjfigren＇s syndrome B lymphocytes subsets Disease activity

分类号 R593.2 [医药卫生—内科学]

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