维生素D滴剂预防早产儿维生素D缺乏性佝偻病的效果观察

Effects Observation of Vitamin D Drops on Vitamin D-deficient Rickets of Premature Babies

目的:观察维生素D滴剂预防早产儿维生素D缺乏性佝偻病的效果。方法:137例早产儿按分层随机分组法分为观察组与对照组。对照组51例,给予乳酸钙颗粒0.25 g、bid,连续用药6个月以上;观察组86例,在对照组用药基础上加用维生素D滴剂400 U、bid。随访2年,比较两组早产儿给药前、后血清生化指标如血清25-羟维生素D3(25OHD3)、钙、磷、骨钙素(BGP)、碱性磷酸酶(ALP)及骨源性碱性磷酸酶(BALP)的含量变化和骨密度及佝偻病的发生率。结果:观察组早产儿在给药前,各项血清生化指标的检查结果与对照组比较差异均无统计学意义(P>0.05);给予相应治疗并随访2年后,观察组的各项血清生化指标及骨密度、佝偻病发生率均显著优于对照组(P<0.05)。结论:维生素D滴剂能显著降低早产儿维生素D缺乏性佝偻病的发生率,对预防佝偻病和促进骨质形成有重要的临床应用价值。

OBJECTIVE： To observe the effects of Vitamin D drops on vitamin D-deficient rickets of premature babies. METH- ODS： According to stratified randomization method, 137 premature babies were divided into observation group and control group. 51 cases in control group were given Calcium lactate granules 0.25 g, bid, for consecutive 6 months. 86 cases in observation group were additionally given Vitamin D drops 400 U, bid, on the basis of control group. Followed up for 2 years, the contents of 25OHD3, calcium, phosphorus, BGP, ALP and BALP, bone density, and the incidence of rickets were compared between 2 groups before and after medication. RESULTS： There was no statistical significance in serum biochemical indexes between 2 groups before medication （P〉0.05）. After given drug and followed up for 2 years, serum biochemical indexes, bone density and the incidence of rickets in observation group were significantly better than in control group （P〈0.05）. CONCLUSIONS： Vitamin D drops can significantly reduce the incidence of vitamin D-deficient rickets of premature babies, and it has important clinical value for the prevention of rickets and the promotion of bone formation.