miR-21与头颈部恶性肿瘤

miR-21 and head and neck carcinoma

近年来研究发现miR-21在多种头颈部恶性肿瘤中存在异常表达,该异常表达与甲状腺癌、鼻咽癌、喉癌和口腔癌等头颈部恶性肿瘤的发生发展都存在密切的联系,并且可能对头颈部恶性肿瘤的术前诊断、临床治疗及预后的判断具有重要的价值.

In recent years, the abnormal expression of microRNA-21 （ miR-21 ） in head and neck carcinoma have been found in many studies, which may be closely related to the genesis and development of thy- roid carcinoma, nasopharyngeal carcinoma, laryngocarcinoma and oral carcinoma, etc. MiR-21 may also be valuable for the clinical diagnosis, treatment and prognosis of head and neck carcinoma.