胃泌素与微小RNA在促大肠癌细胞增殖中的关系

Relationship between gastrin and miRNA in promoting colorectal cancer cell proliferation

研究证实异常表达的胃泌素与其受体结合后可激活相应的信号转导通路,促进大肠癌细胞增殖、抑制凋亡,而这一过程也与微小RNA（miRNA）的表达失调相关.研究表明,miRNA在大肠癌中的调控机制与胃泌素促大肠癌细胞增殖的信号通路存在多个交叉点,因此可能存在一条“胃泌素-miRNA-靶基因”信号转导通路.若能对该通路加以了解并对相关因素施以控制,将会为大肠癌的基因靶向治疗开辟一条新的途径.

It has been demonstrated that the combination of abnomal expression of gastrin with its re- ceptor can promote cell proliferation and inhibit apoptosis in colorectal neoplasms via signal transduction path- ways, which is related with the abnormal expression of miRNA. Researches show that there are multiple inter- sections between the molecule mechanisms of miRNA and the signaling pathway of gastrin in promoting colorec- tal cancer cell proliferation. It may exist a ＂gastrin-miRNA-target gene＂ signaling transduction pathway. Knowing the mechanism of the signaling pathway and controlling the related factors will open another avenue for the gene targeted therapy of colorectal neoplasms.