97例HBsAg阳性原发性肝癌患者HBV基因型分析

Analysis of HBV genotype in 97 cases of HBs Ag positive patients with primary hepatocellular carcinoma

目的探讨HBs Ag阳性的原发性肝癌(PHC)患者血清HBV基因分型的特点。方法对97例HBs Ag阳性的PHC患者进行HBV基因型检测。结果 97例患者中,HBV基因B型患者38例(39.1%),HBV基因C型患者54例(55.7%);92例HBV基因B和C型患者中,HBe Ag阳性患者33例(35.9%)。结论 HBs Ag阳性的原发性肝癌患者的HBV基因型主要为HBV基因C型,且血清HBe Ag多为阴性,多有慢性乙型肝炎病史。

Objective To explore characteristics of serum HBV genotype of HBsAg positive patients with primary hepatocellular carcinoma （PHC）. Methods Total of 97 cases of HBsAg positive patients with PHC were detected by HBV genotype. Results In 97 cases, there are 38 cases （39.1%） with genotype B and 54 cases （55.7%） with genotype C. There are 33 HBeAg positive cases （35.9%） in 92 cases of HBV genotype B and C. Conclusions HBV genotype C is mainly in HBsAg positive patients with primary hepatocellular carcinoma and most of them are HBeAg negative and have history of chronic hepatitis B.