TRPV1在电针调节胃运动中的作用

Role of TRPV1 in the Regulation of Gastric Motility by Electroacupuncture

目的探讨香草酸瞬时受体亚型1(transient receptor potential vanilloid 1,或vanilloid recepot 1,TRPV1)在电针调节胃运动中的作用。方法选用TRPV1基因敲除小鼠(KO小鼠)及野生型C57BL/6小鼠(WT小鼠),针刺足三里、曲池、中脘、胃俞穴,观察针刺前后胃内压变化。结果电针WT小鼠足三里穴有兴奋,有抑制,表现为轻度兴奋为主。电针胃俞、曲池和中脘穴均表现为抑制效应。针刺KO小鼠足三里、曲池、中脘、胃俞穴,胃运动方向整体表现均为抑制。结论 TRPV1受体对胃运动有一定的调节作用,针刺TRPV1敲除小鼠可抑制胃运动。

Objective To discuss the role of transient receptor potential vanilloid 1 （TRPV 1） in the regulation effect of electroacupuncture on gastric motility. Method TRPV1 gene knock-out mice （KO mice） and wild-type C57BL/6 mice （WT mice） were selected to receive acupuncture at Zusanli （ST36）, Quchi （LI11）, Zhongwan （CV12）, and Weishu （BL21）, and the intragastric pressure was observed before and after acupuncture. Result Electroacupuncture at Zusanli caused both excitation and inhibition in WT mice, predominated by mild excitation, while electroacupuncture at Weishu, Quchi and Zhongwan all caused inhibition effect; in the KO mice, electroacupuncture at Zusanli, Quchi, Zhongwan, and Weishu all inhibited gastric motility. Conclusion TRPV1 bears certain regulating effect on gastric motility, and acupuncture can inhibit the gastric motility in TRPV gene KO mice.