中医疗法治疗溃疡性结肠炎缓解期的Meta分析

Meta- analysis of Ulcerative Colitis Remission Treated with Traditional Chinese Medicine Therapy

目的运用Meta分析综合评价中医疗法治疗溃疡性结肠炎缓解期效果分析。方法收集国内期刊发表的有关于中医疗法治疗溃疡性结肠炎缓解期的的临床试验的文章,运用Jadad质量标准对文献进行评价,并利用Rev Man 5.2软件对多个研究结果的总体效应进行Meta分析。结果中药治疗组和西药治疗组比较,临床疗效分析比较:235/267(88.01%),199/269(73.97%),(0R=3.01,95%CI:[1.83,4.97])。复发率;8/171(10.52%),78/172(45.34%),(0R=0.13,95%CI:[0.07,0.23])。不良分析比较:(1.31%),14/75(18.66%),(0R=0.08,95%CI:[0.01,0.43]。敏感性分析:显示评价结果较为稳定;漏斗图图形不对称,考虑存在发表性偏倚。结论中医疗法针对溃疡性结肠炎缓解期有一定的疗效。

Objective： To evaluate the effectiveness of ulcerative colitis remission treated with TCM therapy through meta- analysis. Methods：The articles published in domestic journals about clinical tests of ulcerative colitis remission treated with TCM therapy have been collected and evaluated by using Jadad quality criteria. A meta - analysis of the overall effect of multiple studies was made by RevMan 5.2 software. Results：The clinical effective comparison of the TCM treatment group and the western medicine treatment group was 235/267 （88.01%）, 199/269 （73.97%）, （OR =3.01,95% CI：[1.83,4.97]）. Relapse rate was 8/171（10.52%）,78/172（45.34%）,（OR= 0.13,95% CI： [ 0.07,0.23 ] ）. Adverse analysis and comparison was （ 1.31% ）, 14/75 （ 18.66% ）, （OR = 0.08,95 % CI ： [ 0 01,0.43 ]. Sensitivity analysis was that the displayed evaluation results were more stable, funnel plot graphics was asymmetric and the consideration had publication bias. Conclusion ：Traditional Chinese medicine therapy has a certain effect on the treatment of colitis remission patients.