肺泡内液体清除与肺水肿的研究进展

Progress in alveolar fluid clearance and pulmonary oedema

肺水肿是急性肺损伤(ALI)病理进程中的中心环节,与肺泡毛细血管通透性增加和肺泡内液体清除减少有关。以往对肺泡毛细血管通透性导致的肺水肿研究较多,而对肺泡内液体清除在肺水肿形成中的作用关注不足。肺泡内液体清除受水通道蛋白、钠离子通道、钠钾ATP酶的影响。认识肺泡内液体清除机制有望能为临床医师治疗ALI提供参考。

Pulmonary edema is a so much hallmark event in pathology process of acute lung injury （ALI）, which is associated with a increased alveolar-capillary permeability and decreased alveolar fluid clearance. The research of pulmonary edema mediated by alveolar-capillary permeability was much more than formation of pulmonary edema mediated by alveolar fluid clearance in past. Lung edema clearance is affected by aquaporin （AQP）, epithelium Na＋ channel （ENaC） and Na＋-K＋-ATPase. The understanding of how edema is cleared from the alveoli may provide a reference in treating ALI for clinicians.