不同剂量阿托伐他汀对家族性高胆固醇血症的降脂疗效评价

Effects of Different Doses of Atorvastatin on Lipid Lowering Efficacy Observation of Heterozygous Familial Hypercholesterolemia

目的:探讨阿托伐他汀的不同剂量对杂合子家族性高胆固醇血症(familial hypercholesterolemia,FH)的降脂效果。方法:选取家族性高胆固醇血症患者68例,随机分为观察组和对照组,每组34例。对照组每天给予阿托伐他汀片剂40 mg,观察组每天给予阿托伐他汀片剂60 mg,检测两组空腹外周血总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的含量,并比较用药前后的疗效。结果:治疗一个疗程后,观察组TC、HLD-C、LDL-C分别为(5.12±0.64)mmol/L、(1.25±0.02)mmol/L、(3.13±0.48)mmol/L,与治疗前比较,差异有统计学意义(t=2.898,P<0.05;t=1.762,P<0.05;t=2.954,P<0.05);对照组服药后TC、HLD-C、LDL-C分别为(7.34±0.32)mmol/L、(1.13±0.21)mmol/L、(4.06±0.21)mmol/L,与治疗前比较,差异有统计学意义(t=1.958,P<0.05;t=1.926,P<0.05;t=1.968,P<0.05);治疗后,观察组TC、LDL-C、HDL-C下降水平明显优于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为91.18%(31/34),对照组临床总有效率为82.35%(28/34),两组比较差异有统计学意义(字2=3.968,P<0.05)。结论:阿托伐他汀60 mg/d的剂量对杂合子FH的降脂效果理想,值得临床推广应用。

Objective：To investigate the lipid-lowering effect of Atorvastatin on heterozygous familial hypercholesterolemia（familial hypercholesterolemia,FH）.Method：68 cases with heterozygous FH,were randomly divided into the observation group（n=34） and the control group（n=34）.The observation group was given Atorvastatin tablets 60 mg,the control group was given Atorvastatin tablets 40 mg,detection of total cholesterol in each dosage group fasting peripheral blood（TC）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）, efficacy was compared before and after treatment.Result：After one course of treatment,the observation group TC,HLD-C,LDL-C were （5.12±0.64） mmol/L,（1.25±0.02）mmol/L,（3.13 ±0.48）mmol/L,compared with before treatment,there were statistical significance（t=2.898,P〈0.05;t=1.762,P〈0.05;t=2.954,P〈0.05）.The control group after administration of TC,HLD-C,LDL-C were （7.34±0.32）mmol/L,（1.13±0.21）mmol/L, （4.06±0.21）mmol/L,compared with before treatment,there were statistical significance（t=1.958,P〈0.05;t=1.926,P〈0.05;t=1.968,P〈0.05）. The comparison between two groups,the observation group TC,LDL-C,HDL-C decreased significantly than that in the control group,with statistical significance（P〈0.05）.The total clinical effective rate of the observation group was 91.18%（31/34）,the total clinical effective rate of the control group was 82.35%（28/34）,there was statistically significant difference between two groups（χ^2=3.968,P〈0.05）.Conclusion：The ideal lipid-lowering effect of Atorvastatin 60 mg/d dose of FH heterozygotes,is worthy of clinical application.