中西药结合治疗颈淋巴结结核伴寒性脓肿的疗效分析

Effect analysis of combined treatment of traditional Chinese medicine and western medicine on tuberculosis of cervical lymph nodes with cold abscess

目的 观察中西药结合联合治疗颈淋巴结结核伴寒性脓肿的治疗效果.方法 研究对象为20072012年在连云港市第四人民医院住院及门诊治疗的64例颈淋巴结结核伴寒性脓肿患者.将患者以数字表法随机分为2组.单纯西药治疗组（简称“对照组”）32例,患者给予4HRZE/8HR抗结核治疗,局部创面采用外科清创后异烟肼（50 mg/ml）溶液冲洗,再用油纱条填塞;中西药结合治疗组（简称“中西药治疗组”）32例,给予4HRZE/8HR±结核灵抗结核治疗,局部创面采用外科清创后异烟肼（50 mg/ml）溶液冲洗加含有自制中药丹药（主要成分为煅石膏、黄丹、血竭、冰片等）油纱条填塞.分别统计两组患者治愈率、复发率.采用STATA 8.0统计软件进行统计分析,率的比较采用x^2检验,P＜0.05为差异有统计学意义.结果 单纯西药治疗组治愈率53.13％（17/32）;中西药治疗组治愈率81.25％（26/32）,中西药治疗组治愈率高于单纯西药治疗组,差异有统计学意义（x^2=6.74,P＜0.05）.单纯西药治疗组复发率为35.29％（6/17）,中西药治疗组复发率为7.69％（2/26）,中西药治疗组复发率低于单纯西药治疗组复发率,两组比较差异有统计学意义（x^2=5.17,P＜0.05）.结论 采用结核灵、自制中药丹药及一线抗结核药物等中西药结合方法治疗颈淋巴结结核伴寒性脓肿的临床治愈率高于单纯西药治疗组,复发率低于单纯西药治疗组.

Objective To observe the effect of combined treatment of traditional Chinese medicine and western medicine on tuberculosis of cervical lymph nodes with cold abscess.Methods Sixty four patients with tuberculosis of cervical lymph nodes and cold abscess who were treated in our hospital in the past four years （20072012） were study objects.They were randomly divided into 2 groups.The patients in the first group （control group） didn＇t adopt traditional Chinese medicine,they were treated by 4HRZE/8HR regimen,after surgical debridement local wound was performed the isoniazid （50 mg/ml） flushing followed by oil gauze tamponade.The patients in the second group （combined treatment group） adopted 4HRZE/8HR and traditional Chinese medicine Jieheling,after surgical debridement local wound was performed the isoniazid （50 mg/ml） flushing followed by oil gauze tamponade with traditional Chinese medicine pills （the major constituents were calcined gypsum,yellow lead,dragon＇s blood and borneol,etc.）.STATA 8.0 was used for analysis.Chi square test was apllied to compare the difference of cure rates and relapse rates of the two groups,P〈0.05 was considered statistically significant.Results The cure rate of the combined treatment group （81.25%,26/32） was significantly higher than that of the control group （53.13%,17/32） （x^2 6.74,P〈 0.05）.The relapse rate of the combined treatment group （7.69%,2/26） were significantly lower than the control group （35.29%,6/17） （x^2 5.17,P〈0.05）.Conclusion Combined treatment of traditional Chinese medicine and western medicine on tuberculosis of cervical lymph nodes with cold abscess has higher cure rate and lower relapse rate than western medicine treatment.