测定C反应蛋白在慢性阻塞性肺病急性加重期COPD的临床意义

Clinical value in acute exacerbations of chronic obstructive pulmonary disease by determining the concentration of C-reactive protein

目的：探讨测定C反应蛋白（ C－reactive protein，CRP）在急性加重期慢性阻塞性肺病（ chronic obstructive pulmonary disease，AECOPD）的临床意义。方法：回顾性分析60例急性加重期的COPD患者的血液检测结果。分别在患者入院后第2天及经抗生素抗感染治疗后采血，同时动态监测患者的中性粒细胞百分比、白细胞计数、血沉及CRP浓度的变化情况。组间均数采用卡方检验分析，以P＜0．05为统计学具有显著性差异。结果：急性加重期COPD患者的CRP浓度明显高于经抗生素抗感染控制期的COPD患者（P＝0．007）；CRP浓度的阳性率明显高于其他血液常规检测指标，两两间具有统计学差异（P＜0．05）。结论：CRP浓度对急性加重期COPD患者的感染极为敏感，并有望成为今后判断COPD患者疗效及其感染的早期发现的指标之一。

Objective：To explore the clinical value in acute exacerbations of chronic obstructive pulmonary disease （ COPD） by deter-mining the serum concentration of C-reactive protein （ CRP） .Methods：The data of blood detection in sixty patients with acute exacerba-tions of COPD were retrospectively analysed.Blood sampling should be taken after 2 day-admission and after infection treatment with an-tibiotic resistance respectively.Meanwhile,the temperature,neutrophilic granulocyte percentage,white blood cell count,erythrocyte sedi-mentation rate and the concentration of the CRP shou be dynamic monitoring.Mean differences between groups by chi-square test analy-sis.The significant statistical differences was definited With P〈0 0.5 .Results：The value of serum CRP in acute exacerbations of COPD patients was apparently higher than the COPD patients after infection treatment with antibiotic resistance（P=0.007）.The positive rate of the concentration of CRP was higher than other blood routine test indicators,the P value was P〈0.05.Conclusion：The concentration of CRP,sensitive to the infection of the acute exacerbations of COPD,was hopeful to be one of the sensitive index to estimate the curative effect and the early detection of infection of the COPD patients in the future.