生地黄历代临床用量分析

Analysis of Clinical Dosage of Unprocessed Rehmannia Root in Past Dynasties

目的总结从两汉至今生地黄的临床用量特点,为生地黄临床用量策略的制定提供依据。方法采用Microsoft office excel 2007软件建立历代生地黄剂量数据库,选取各朝代最具代表性的医学著作,将含生地黄方剂的方名、总药量、生地黄药量、整方药味数、加水量、服法等逐一录入。统计生地黄出现的频次、最常用量、常用量上限、常用量下限、最大用量、最小用量、平均用量。结合文献分析生地黄历代用量特点。结果汉唐时期生地黄用量特点为大剂量（〉41.4 g）、宽范围（10.4-414.6 g）,而从宋代至今,生地黄临床用量虽有所波动但总体呈较低水平,表现为平均用量、最常用量下降,常用量范围缩小,但用量范围仍较宽。结论生地黄使用25 g左右主要发挥滋阴清热凉血的作用,30 g以上有除痹安神的作用。

Objective To conclude the characteristics of clinical usage of unprocessed rehmannia root since the HaM Dynasty and to provide a basis for the formulation strategy of its clinical dosage. Methods A database including dosage of unprocessed rehmannia root of every past dynasty was established by selecting medical literatures that are most representitive of each dynasty and entering the name, overall dosage, dosage of unprocessed rehmannia root, number of Chinese medicinals, volume of water added, administration method of all formulas with unprocessed rehmannia root successively. Frequency of occurrence, dosage most commonly used, upper limit of dosage, lower limit of dosage, maximum dosage, minimum dosage and average dosage of unprocessed rehmannia root were caculated. The characeristic of dosage for past dynasties was analyzed with literature. Results In HaM and Tang dynasty, unprocessed rehmannia root was used in high dose （〉41.4g） and in a wide range. However, from Song dynasty till nowa- days, dosage of unprocessed rehmannia root has been fluctuating yet remained in a lower level, casting as decreased average dosage and dosage most commonly used, with a narrower range of dosage most commonly used, while the range of all dosage fairly wide. Conclusion Using 25 g of unprocessed rehmannia root mainly has the effects of nourishing yin, clearing heat and cooling the blood, while usage of more than 30 g has the effects of dispelling rheu- matism and calming the mind.